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You have a strong connection with someone that makes you feel as if you’ve known them your entire life. This sense is a sign that you are within a soulmate connection.

You can be yourself around them. They compliment you on your most unlikely characteristics and accept you as your eccentric self.

next Date Rules

If you’ve got another date arranged, there are a best countries for mail order brides few circumstances to keep in mind for making it the very best one yet. First, typically go with this dinner and a movie factor unless you find out your day likes these items. Aim for some thing creative which will give you both equally a chance to my university in different methods, and set the stage for the future of your romantic relationship. Second, be sure you connect your the case feelings about your day and ideal important to you early on. This will prevent misconceptions and conflicts at a later date. It will also help him feel good about himself and possess that you value him. This will make him more likely to fight for you. This is the key to a soulmate connection.

Engagement Party Etiquette

Many lovers choose to variety engagement parties to celebrate their fresh status and possess off all their rings. Traditionally, involvement parties happen to be hosted by bride’s parents. This can be a great way to propose the future granparents and begin building links between families.

It’s the chance for the couple to appreciate their loved ones with regards to their very own support and also to invite individuals exactly who aren’t individual wedding guest list. Guests can be invited with standard paper invitations or perhaps via e-vites, with respect to the type of party you’re organizing.

An individual big thought is whether to incorporate registry data within the invites. A large number of couples will choose to do this, although it’s not essential. her latest blog Actually the couple may want to ask their guests to not ever bring gifts. This is growing to be more usual, as many people prefer to conserve their particular gift-giving with regards to bridal baths or marriage gifts.

In addition , a lot of couples will certainly ask that their friends not exchange badinage, persiflage about marital relationship (i. e., https://www.discovermagazine.com/the-sciences/interracial-divorce-the-matrix-of-sex-and-race “when are you having a wedding? ” or “are you sure this is the right time for kids? ”). This is a good guideline to remember. Maintain the conversation thrilling light, and don’t delve into any controversial issues. You don’t want to spoil the feeling and build any unnecessary pressure.

Site Notes

Although people consider soul mates through a romantic lens, it’s important to remember that this type of profound connection isn’t just designed for couples. In fact , you could have a soulmate in all types of relationships, which include family members, close friends, mentors, and organization partners.

Nunez says that platonic soul mates will be your best friends who you “recognize on a psychic level. inches They’ll accomplish the sentences and they’re going to always “get” you, the girl adds. These are generally friendships that will provide you with support through life’s troubles, and they offer a feeling of calmness and nurture.

If you’ve had a soulmate in your personal life or in your professional career, you have to thank them for anyone that they are yet to done for everyone. You may send all of them a simple text message, email, or handwritten standard to show the appreciation for his or her assistance and support.

When some experts, like Jessica Small , an authorized marriage and family therapist with Growing Do it yourself Counseling and Coaching, disagree armed with the idea of soul mates and twin flames because they can result in an unhealthy self-belief that there’s only one person who’s most likely going for you, a great bond university with your real guy can be very healthful for your romantic relationship.

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The 1xBet Casino does not have mobile on line casino tournaments in the meanwhile. Perhaps these might be introduced in the future, but in case you are actually excited about tournaments then different apps/web-apps offered by 1xBet offer tournaments, such as the 1xBet Poker App. The quickest and easiest approach to contact customer assist is thru stay chat, which is out there 24/7. As we have talked about any good options about this website are irrelevant simply down to the reality that 1xBet presents a platform for blood sports activities within the form of cockfighting. Customer service is on the market through 24/7 stay chat but leaves a lot to be desired.

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There are huge benefits of including 1xBet to your list of eSports suppliers. In terms of eSports video games, 1xBet has much to provide as you will note beneath.

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As part of the loyalty program, 1xBet online on line casino has launched one other “VIP Cashback” promotion. The phrases of the promotion assume that regular prospects will obtain a partial refund of their very own funds spent over a sure interval.

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They received a criticism that he allegedly sexually assaulted a waitress in a bar. 1XCorp, the proprietor of 1XBet, was declared bankrupt by a court docket in Curaçao final 12 months.

For example, Terminus Platform is a company in Madrid, Spain. The nature of the connection between the sportsbook and the Russian regime is still open for debate. Last December, Brazilian soccer pro Dani Alves, who has played for Barcelona and PSG, grew to become its ambassador. That would possibly quickly end, as police in Barcelona arrested him last Friday.

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It ran out of cash final yr and is now dealing with definitive courtroom motion that might convey it to an end. This was after it had already faced compelled exits in the UK and different countries. Indeed, I would advise you to ask for help on how to get them.

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Mi az a Chagas -kór? A

Mi az a Chagas -kór? A

chagas -kór, vagy az amerikai trypanosomiasis olyan állapot, amely fokozatos szervkárosodást okoz. Kezelés nélkül végzetes lehet.

A betegség a parazita trypanosoma cruzi miatt alakul ki. A triatomin hibák néven ismert vérszívó hibák elterjesztik ezt a parazitát. Ezek a hibák őshonos Latin -Amerikában, ahol a Chagas -kór a legelterjedtebb.

Ez a cikk elmagyarázza, hogy a T. cruzi parazita hol a leggyakoribb, és hogyan terjedhet. Ezenkívül felvázolja a Chagas -betegség tüneteit és a rendelkezésre álló kezelési lehetőségeket.

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Covid-19: Mit tudunk az új coronavírus változatról?

Covid-19: Mit tudunk az új coronavírus változatról?

Az Egyesült Királyságban először az Egyesült Királyságban azonosították a vírus új változatát, amely a COVID-19-et okozza az egész világon. Ebben a különleges szolgáltatásban az orvosi hírek ma megvizsgálják, mit csinálunk – és nem – tudunk erről a változatról és arról, hogy mit kell mondani az egészségügyi szakértők.

Az összes adat és statisztika a közzététel idején a nyilvánosan elérhető adatokon alapul. Néhány információ elavult lehet. Látogasson el a Coronavírus csomópontunkra, és kövesse az élő frissítések oldalunkat a Covid-19 pandémiáról szóló legfrissebb információkkal kapcsolatban.

A közelmúltban a globális média híres volt a SARS-COV-2, a COVID-19ért felelős vírus új változatáról szóló hírekkel és spekulációval.

A variáns, amelyet a kutatók először az Egyesült Királyságban azonosítottak, B.1.1.7 -nek hívják, bár a tudósok aggodalmát fejezték ki amiatt „Az első változat, amelyet 2020 decemberében vizsgáltak.”

A későbbi decemberi kormányzati dokumentumok „aggodalomra okot adó változatnak” nevezték el, és ezt a VOC 202012/01 -nek nevezték.

B.1.1.7 először az Egyesült Királyságban vették észre. 2020 szeptemberében. December elején kezdte felhívni a tudományos közösség és a kormányzati hatóságok figyelmét, amikor az Egyesült Királyság egészségügyi titkára, Matt Hancock azt javasolta, hogy ez az gyorsan elterjedt, és valószínűleg hozzájárult a SARS-COV-2 fertőzések növekvő számához Anglia déli részén.

Most, a cikk közzétételének idején, az új változatot legalább 60 országban észlelték.

De miért van ez a változat annyira érdeklődésre a tudósok, a közegészségügyi szervezetek és a nagyközönség iránt? Ebben a különleges szolgáltatásban áttekintjük azt, amit eddig tudunk a B.1.1.7 -ről, és megvizsgáljuk azokat a kérdéseket, amelyekre a tudósok még mindig megpróbálnak válaszolni.

Az alábbiakban megvizsgáljuk, hogy mi a vírusmutációk, hogyan kapcsolódnak az új vírustörzsek kialakulásához, és hogy az Egyesült Királyságban azonosított új SARS-COV-2 változat aggodalomra ad okot.

Az MNT is kapcsolatba lépett a Pfizerrel és a Nemzeti Allergia és Fertőző Betegségek Intézettel (NIAID), hogy megtudja, hogy az Egyesült Államokban és Európában jelenleg elérhető COVID-19 vakcinák hatékonyak lesznek-e a B ellen. .1.1.7. Tudja meg, mit kellett mondania nekünk.

cikk összefoglalása:

Miért mutálnak a vírusok?

vírusok hajlamosak a mutációkra. Valójában az összes genetikai anyag, beleértve az embereket is, mutálhat, amikor hibák fordulnak elő a replikáció során.

A vírus mutációja akkor fordul elő, amikor a genetikai szekvenciája megváltozik. Ez variációt hoz létre és meghajtja a vírus evolúcióját. A

mutációk a vírusgenetikai kódban kódolt fehérjék változásaihoz vezetnek. Ezek a változások lehetnek előnyös, káros vagy semlegesek.

Hány mutációra van szükség a vírus új törzsének előállításához? Ezt nem könnyű megválaszolni, részben azért, mert a tudósok nem értenek egyet a „törzs” szó meghatározásával kapcsolatban.

Általánosságban, ha egy vírusnak elegendő mutációja van ahhoz, hogy biológiája szignifikánsan eltérő legyen, akkor új törzsnek tekinthető. Ez azt jelenti, hogy másképp reagálhat az oltásokra vagy a kezelésekre, vagy más fajokat megfertőzhet, vagy más módon továbbíthatja.

De ha a vírus biológiája nagyjából változatlan marad, a mutációk ellenére a „variáns” kifejezés tudományosan pontosabb lehet.

A járvány kezdete óta sok vita folyt a SARS-COV-2 mutációkról és arról, hogy milyen következményekkel járhat. A

SARS-COV-2, mint sok más koronavírushoz hasonlóan, van egy enzim, amely a replikáció során leolvasta genetikai kódját, csökkentve a mutációk sebességét.

Míg az új coronavírusnak viszonylag stabil genomja van, összehasonlítva más vírusfajtákkal, néha mutál, és a tudósok szorosan figyelemmel kísérik ezeket a változásokat.

Az egyik legszélesebb körben beszélt a mutációkról a D614G változathoz vezetett. Ez megváltozik a tüskefehérjében, amely kölcsönhatásba lép az ACE2 receptorral az emberi sejteken, hogy megkönnyítse a vírus belépését.

Különösen a tüskefehérjében lévő aminosav a 614 helyzetben az aszparaginsavról glicinre változik.

Dr. Bette Korber kutatása, a Los Alamos Nemzeti Laboratóriumból, Új -Mexikóban, és kollégái azt sugallják, hogy ez a változás lehetővé teszi a változat számára, hogy könnyebben megfertőzze az embereket.

A D614G változat a SARS-COV-2 világszerte az uralkodó változatává vált, a kutatás azt mutatja.

A csapat adatai azt mutatják, hogy a vírus D614G -változatával rendelkező embereknél magasabb a vírus RNS -szintje, mint az eredeti változatban. De nincs bizonyíték arra, hogy ez súlyosabb Covid-19-et okoz.

Mégis, nem minden tudós ért egyet a csoport értelmezésével. A cikkre hivatkozva Dr. Nathan Grubaugh, a Yale Közegészségügyi Iskolából, a New Haven -ben, a CT -ben és a kollégák megjegyezte, hogy további kutatásokra van szükség annak alátámasztására, hogy ez a változat valóban jobban terjedő.

Miközben a kutatók továbbra is tanulmányozzák a D és G variánsok közötti különbségeket, a világ a B.1.1.7 felé fordult, és hogyan alakíthatja ki a pandémiát.

B.1.1.7 és az alapító effektus

A B.1.1.7 változat 23 mutációval rendelkezik. Hat nem okoz változást a vírus aminosavszekvenciájában. A fennmaradó 17 mutáció közül nyolc befolyásolja a tüskefehérjét.

Az N501Y változás, amely magában foglalja az aszparaginról a tirozinra való váltást az 501 helyzetben, a tüskefehérje receptor-kötő doménjében található. Ez egy kritikus szakasz, mivel közvetlenül kölcsönhatásba lép az ACE2 receptorral.

Egy másik mutáció az RNS -ben, amely a tüskefehérjét kódolja, lehetővé teszi a kutatók számára, hogy a polimeráz láncreakció (PCR) tesztmintáinak ezt a variánst kimutatják. Ennek oka az, hogy a mutáció az egyik célzott területen rejlik, amelyet sok diagnosztikai PCR -teszt használ.

Ezek a tesztek más célokat is használnak, általában legalább kettő kombinációját. A tudósok olyan PCR -teszteket kereshetnek, amelyek negatívak a tüske -szekvencia szempontjából, de pozitívak a többi célra. Ez azt jelzi, hogy a személynek a SARS-COV-2 vírus B.1.1.7 változata van.

Az Anglia közegészségügyi kutatói ezt a módszert használták a brit népességben a változat terjedésének nyomon követésére, és megbecsülni, hogy az átterjedhetőség hogyan összehasonlítható a korábbi variánsokkal.

De annak tanulmányozása, hogy a vírus milyen könnyen továbbítja az egyik embert a másikra, technikailag kihívást jelent. Az epidemiológiai adatok modelleket tudnak nyújtani, és a fertőzés dinamikájának laboratóriumi vizsgálata részletesebben felfedheti. Az ilyen tanulmányok folyamatban vannak.

Egyes tudósok megkérdőjelezték, hogy a B.1.1.7 változat magasabb -e a transzmissziós képességgel, ami arra utal, hogy a fertőzés eseteinek magas száma az alapító hatásából származhat.

Az alapító hatás egy olyan kifejezés, amelyet az evolúción tanulmányozó tudósok használnak. Megállapítja, hogy az egyének kis csoportja új populációt eredményezhet.

A vírusok összefüggésében az alapító hatás megmagyarázhatja, hogy a B.1.1.7 hogyan terjedt el ilyen gyorsan. A kutatók azt sugallták, hogy az egész Angliában az egész Angliában a fertőzés aránya és a fertőzés aránya lehet a B.1.1.7 változat ilyen nagyszámú fertőzésének.

Két szakértővel beszéltünk erről.

“Noha ezt kezdetben úgy gondolták, amikor a változatot először szeptemberben azonosították, a bizonyítékok egyre inkább azt mutatták, hogy ez valószínűtlen, és most már nagyrészt kizártak. Az Egyesült Királyságban a fertőző betegség a higiéniai és trópusi orvoslás (LSHTM) Londoni Iskolájában (LSHTM) mondta.

Prof. Jonathan Stoye, a londoni Francis Crick Intézet csoportvezetője, akinek a laboratóriumi tanulmányok vírus-host interakciói visszhangzották ezt az érzetet. “Kezdetben azt hittem, hogy ez a helyzet” – jegyezte meg, és hozzátette:

“Bár ez hozzájárulhat az új változat kezdeti terjedéséhez, valószínűtlennek tűnik, hogy megmagyarázza az eset előfordulását, az eset előfordulását, Tekintettel a változat egyidejű növekedésére több beállításban. Inkább úgy tűnik, hogy valószínű, hogy a vírus felszabadulásának magasabb szintje, amely talán több sejt fertőzéséből származik, magasabb vírusátadási arányhoz vezet. ”

– Prof. Jonathan Stoye

Pontosan hogyan különbözik a B.1.1.7?

Sok kérdés a B.1.1.7 -ről. marad. Hogyan lehet összehasonlítani a már létező törzsekkel, a transzmissziósság szempontjából? Valószínűleg súlyosabb Covid-19-et okoz? A gyerekek sebezhetőbbek -e ezt a változatot? A rendelkezésre álló kutatás

Úgy tűnik, hogy az új változat magasabb az átviteli képességgel.

Egy tanulmány, amelyet még nem kell áttekinteni, de 2020. december 26-án elérhetővé vált a Preprint szerveren, a matematikai modellezést használták az új variáns transzmissziósságának becslésére SARS-CoV-2.”

Az LSHTM kutatócsoportja arra a következtetésre jut, hogy a B.1.1.7 „56% -kal transzmissziós” változat, mint más SARS-COV-2 változat.

Eközben egy jelentés, a Londoni Imperial College-ból származó preprint formában is, a jelenleg rendelkezésre álló epidemiológiai és genetikai adatokat vizsgálja, és szintén azt a következtetést vonja le, hogy COV-2.

A kutatók becslése szerint a B.1.1.7 50–75% -kal átvihetőbb, és elemzésükben figyelembe veszik az alapító hatást. Adataik azonban ennek a változatnak a korábbi variánsokkal szembeni versenyelőnye mellett állnak, a megnövekedett transzmissziósság alapján.

Dr. Julian W. Tang, a Leicesteri Egyetem klinikai virológusa azonban az Egyesült Királyságban figyelmeztette, hogy „még mindig nehéz elválasztani az emberi viselkedést és a vírusgenetikai hozzájárulást, mint a továbbfejlesztett javult okokat. Átadási képesség minden populációban ”, hozzátéve, hogy„ a gyakorlatban csak ezzel kell foglalkoznunk ”.

A közegészségügyi Angliából származó információk utoljára 2020. december 29 -én frissítették, megjegyzi, hogy „jelenleg […] nincs bizonyíték arra, hogy a változat nagyobb valószínűséggel súlyos betegséget vagy halálozást okoz”, bár a további vizsgálatok folyamatban vannak –

Hibberd professzor azt mondta az MNT-nek, hogy az Egyesült Királyságból származó meglévő adatok alapján az új változat nem tűnik a Covid-19 súlyosabb eseteihez, összehasonlítva a SARS-COV-2 más változataival vagy törzseivel –

“A fertőzés esetének halálozási aránya, amely a [fertőzéssel rendelkező] emberek számának közösségi népesség-alapú becslésein és a megfigyelt halálesetek számán alapul-az Egyesült Királyságban az adatok alapján becsülve– Úgy tűnik, hogy nem változott jelentősen, ami azt sugallja, hogy az új változat nem okoz súlyosabb betegséget ” – mondta.

Ugyanakkor figyelmeztette, hogy a pontos összehasonlító adatokat nehéz összegyűjteni, elmagyarázva:

“A betegség súlyosságának pontosabb becslései az idő múlásával felépülnek, a megfigyelt adatok alapján Az új és a régi variánsok közvetlen összehasonlítása. Mivel azonban a régi változat ritkává válik az Egyesült Királyságban, ez egyre nehezebbé válik. Ahogy a változat más országokba érkezik, például az Egyesült Államokba, további adatok lesznek [elérhetőek]. ”

Hatás a közegészségügyi intézkedésekre

A fertőzések gyors terjedése az Egyesült Királyságban – nagyrészt a B.1.1.7 változatban hibáztatva – 2020 december folyamán először a korlátozások helyi szigorításához vezetett. , majd a szigorú lezárások végrehajtására Angliában és Skóciában. Írország meghosszabbította az országos zárolását, szigorúbb szabályokkal.

Az LSHTM tanulmány preprint verziójában a kutatók figyelmeztetik, hogy az új változat látszólag nagyobb transzmissziós képessége miatt „a meglévő kontroll intézkedések [a vírus terjedésének tartalmazzák], és az országok az országok, és az országok országok, és az országok országok Erősebb proaktív beavatkozást igényelhet az azonos szintű ellenőrzés elérése érdekében. ”

A 2020. december 31 -én közzétett nyilatkozatában az Egészségügyi Világszervezet (WHO) megjegyezte, hogy több ország már megteszi, hogy milyen intézkedéseket tud a játék előtt.

Azok az országok, amelyek megfigyelték az új vírusváltozatok terjedését, „fokozott mintavételt mutatnak annak megértése érdekében, hogy ezek az új variánsok milyen széles körben keringnek”, és a tudósok felgyorsították az erőfeszítéseket, hogy megértsék, hogy az új SARS-COV-2 variánsok hogyan vagy hogyan A nyilatkozat szerint befolyásolhatja az átvitelt, a betegség súlyosságát és az oltás hatékonyságát.

A WHO azt is javasolta, hogy „a kockázati kommunikáció és a közösségi elkötelezettség tevékenységeit meg kell méretezni a SARS-COV-2 variánsok közegészségügyi következményeinek a nyilvánosság számára, és hangsúlyozzák a folyamatos megelőző intézkedések fenntartásának fontosságát az átvitel csökkentése. ”

Egy megválaszolatlan kérdés a B.1.1.7 -ről a gyermekek új változat iránti érzékenységére vonatkozik.

Az Egyesült Királyságban az iskolák nagyrészt nyitottak voltak az őszi időtartam alatt, de a közelmúltban a legtöbb gyermek számára bezártak. Egyes tudósok azt sugallták, hogy a gyermekek nagyobb valószínűséggel alakulnak ki a B.1.1.7 fertőzéssel, mint a SARS-COV-2 korábbi változataival.

A tudományos közösség között azonban nincs konszenzus.

„Mivel a gyerekek gyakran tünetmentesek, nehéz volt megbecsülni valódi populáció-alapú fertőzés arányát. Úgy tűnik, hogy a kezdeti adatok azt sugallják, hogy egyre több tinédzser pozitívvá válik, de az adatok jelenleg nem egyértelműek ” – magyarázta Hibberd professzor.

Prof. Stoye megosztotta ezt a nézetet: „Mivel egy átterjedtebb vírust adva, elkerülhetetlennek tűnik, hogy több gyermek [fertőzéssel rendelkezik] az új változatmal, majd ezt továbbadja a családjuknak. Nem tudom kommentálni a fertőzés hatását az egyes gyermekek egészségére; További tanulmányok […] lesz szükség a kérdés megoldásához. ”

covid-19 oltások és az új változat

Stoye professzor szerint aggodalmak vannak, hogy a jelenleg felhatalmazott vakcinák nem lehetnek olyan hatékonyak a SARS-COV-2 új változataival szemben, mint Ellenállnak a már létező variánsok ellen, amelyek a klinikai vizsgálatok során végzett tesztelés során részt vettek.

„Az egyik aggodalomra ad okot annak a lehetősége, hogy az új variánsok csökkent érzékenységet mutatnak az immunválaszokkal szemben a nemrégiben bevezetett oltásokkal szemben” – mondta Stoye professzor az MNT -nek. “Noha valószínűtlennek tűnik, hogy a jelenlegi variánsok elmenekülnek, a jövőbeli variánsok ezt megtehetik.”

“Fontos lesz az új vírusok megfigyelése a szérum [vérkomponens] általi semlegesítéséhez oltott egyéneknél. A jövőben szükség lehet az oltóanyag -összetétel megváltoztatására az influenzával, de remélhetőleg nem olyan gyakran ” – tette hozzá.

mnt felvette a kapcsolatot a Nemzeti Egészségügyi Intézetek (NIH) szervezettel, a Moderna biotechnológiai társasággal együttműködve egy COVID-19 vakcina létrehozásában, amely jelenleg felhatalmazott az Egyesült Államokban és az Egyesült Államokban.

„A NIAID tudósok kommunikáltak az Egyesült Királyság kormányának a közegészségügyi Anglia társaival, hogy szorosan nyomon kövessék a SARS-COV-2 VOC 202012/01 megértését, más néven az Egyesült Királyság változatát.

Jelenleg a NIAID tudósok úgy vélik, hogy a SARS-COV-2 oltások, amelyeket a működési lánc sebessége támogat, [OWS], védelmet nyújtanak a SARS-COV-2 VOC 202012/01 ellen, beleértve az OWS-támogatott moderna-t és Pfizer-Biontech Covid-19 oltások, amelyeket az Egyesült Államok Élelmezési és Gyógyszerügynökségének vészhelyzeti felhasználására engedélyeznek [FDA]. ”

“Az ember immunválaszának részeként a vakcinára vonatkozóan sok antitestet termelnek, amelyek a SARS-COV-2 vírus felületén lévő tüskefehérje különböző helyeihez kötődnek. Még akkor is, ha egy SARS-COV-2 variánsnak van néhány mutációja, amelyek megakadályozzák egyes antitestek kötődését, a tudósok azt várják el, hogy más, különböző kötési tulajdonságokkal rendelkező antitestek semlegesítik a vírust ”-mondta Niaid az MNT-nek is.

A Pfizer Pharceutical Corporation, akinek a Covid-19 oltása-a Biontech biotechnológiai társasággal együttműködve-engedélyt kapott az Egyesült Államokban, az Egyesült Királyságban és az Európai Unióban:

“A SARS-COV-2 vírus új változatának azonosítása nem befolyásolja a Pfizer és a Biontech COVID-19 mRNS vakcinának a BNT162B2 bevezetését. Az egészségügyi szakembereknek azt javasoljuk, hogy továbbra is kövessék a vakcina adminisztrációjával kapcsolatos hivatalos útmutatást. ”

Hozzátették, hogy „a társaságok [Pfizer és Biontech] megfigyelik a SARS-COV-2 sorozatváltozásokat, és azon dolgoznak, hogy adatokat generáljanak, hogy felmérjük, hogyan értékeljükA BNT162B2 -vel immunizált emberek széruma képes lehet semlegesíteni az új törzset. ”

reményteljes megállapítások és adaptálható technológia

A Galvestoni Texasi Egyetemi Ügynökség tudósaival együttműködve a Pfizer nemrégiben kiadott egy tanulmányt, amely jelenleg preprint formában volt. N501Y mutáció.

Az önkéntesek szérummintáinak felhasználásával, akik klinikai vizsgálatban kaptak Pfizer-Biontech Covid-19 oltást, a kutatók elemezték, hogy a mintákban az antitestek mennyire jól tudják semlegesíteni a SARS-COV-2 vírust.

Megállapították, hogy a szérumnak „ekvivalens semlegesítő titerjei vannak”, ami azt jelenti, hogy ugyanolyan mennyiségű szérum képes volt semlegesíteni mind az eredeti vírust, mind a mutáns variánsot. Ez azt jelzi, hogy a vakcina ugyanolyan jól fog működni a változat ellen.

A csapat azonban csak az N501Y mutációt vizsgálta izolációban, és a B.1.1.7 számos mutációval rendelkezik a tüskefehérjében.

A 2020. december 22-i sajtótájékoztatón Dr. Uğur şahin, a Biontech vezérigazgatója elmagyarázta, hogy a társaság korábban számos SARS-COV-2 változatmal kombinálva tesztelte oltását, és megtalálta, és megtalálta Hogy ez jól működött ezek ellen. Ezek az eredmények preprint formában érhetők el.

Dr. şahin hozzátette, hogy a vállalat könnyen adaptálhatja oltóanyag -platformját az új variánsok leküzdésére.

A Pfizer-Biontech Covid-19 oltás mRNS technológián alapul. Ez azt jelenti, hogy a vakcina egy kis mennyiségű SARS-COV-2 genetikai kódot tartalmaz, amelyet egy laboratóriumban állítanak elő. Miután oltásként befecskendezték, ez a kód arra utasítja a saját sejtjeinket, hogy készítsék a vírusos tüskefehérjét.

immunrendszerünk reagál erre a gyártott tüskefehérjére, és immunitást épít fel a SARS-COV-2 vírusra. A vakcina nem okozhat Covid-19-et, mert nem tartalmaz élő kórokozókat.

Technikailag nem lenne nehéz megváltoztatni a genetikai kód szekvenciáját a vakcinában, hogy megfeleljen az új változatnak. Dr. şahin becslése szerint ez körülbelül 6 hétig tart. Megjegyezte azonban, hogy az egészségügyi hatóságoknak, mint például az FDA, jóvá kell hagyniuk a vakcinában bekövetkező bármilyen változást.

2021. január 25 -én a Moderna sajtóközleményt is közzétett, amelyben bejelenti, hogy vakcinájuk hatékony a B.1.1.7 változat ellen. “A Moderna Covid-19 oltás kétdózisú kezelése a 100 [mikrogramm] dózison várhatóan védi a mai napig észlelt feltörekvő törzsektől”-állítják.

A társaságnak még nem tett közzé ezeket az állításokat alátámasztó adatokat. Ennek ellenére a moderna tisztviselők azt is elmondták, hogy „óvatosan” elindítanak egy klinikai programot, amelyben továbbra is tesztelik a vakcinák hatékonyságát az új SARS-COV-2 változatokkal szemben, és hogy a vállalat célja, hogy növelje az oltás produkcióját. a titerek semlegesítése az ilyen variánsok ellen.

Az 1. fázisú klinikai vizsgálatban a Moderna tehát megvizsgálja, hogy a törzs-specifikus tüskefehérjék elszámolása javítja-e a vakcina hatékonyságát.

Az AstraZeneca és az Oxford Vaccine Group gyógyszeripari vállalat nem válaszolt az MNT -re a B.1.1.7 változat elleni oltás hatékonyságával kapcsolatban.

Egy újabb új változat

Míg a hírek nagy része a B.1.1.7 -re összpontosított, újabb új változat alakult ki. Az első Dél -Afrikában azonosított B.1.351 -es változatban az N501Y aminosav változása is megváltozik a tüskefehérjében.

Két további mutációval is rendelkezik a régióban, és további aggályokat vált ki azzal kapcsolatban, hogy mennyire lesznek hatékony oltás. Számos tudományos szakértő elmondta az Egyesült Királyságban a Tudományos Média Központnak, hogy úgy vélik, hogy a meglévő Covid-19 oltások azonban leküzdhetik ezt a változatot.

Inc -vel

COVID-19: Τι γνωρίζουμε για τη νέα παραλλαγή κοράνιου;

COVID-19: Τι γνωρίζουμε για τη νέα παραλλαγή κοράνιου;

Πρώτα προσδιορίστηκε στο Ηνωμένο Βασίλειο πέρυσι, μια νέα παραλλαγή του ιού που προκαλεί COVID-19 έχει αυξήσει την ανησυχία του σε όλο τον κόσμο. Σε αυτό το ειδικό χαρακτηριστικό, τα ιατρικά νέα σήμερα εξετάζουν τι κάνουμε – και δεν γνωρίζουμε – για αυτήν την παραλλαγή και τι λένε οι εμπειρογνώμονες της υγείας.

Όλα τα δεδομένα και τα στατιστικά στοιχεία βασίζονται σε διαθέσιμα στο κοινό δεδομένα κατά τη στιγμή της δημοσίευσης. Ορισμένες πληροφορίες ενδέχεται να είναι ξεπερασμένες. Επισκεφθείτε το κόμβο Coronavirus και ακολουθήστε τη σελίδα Live Updates για τις πιο πρόσφατες πληροφορίες σχετικά με την πανδημία Covid-19.

Πρόσφατα, τα παγκόσμια μέσα ενημέρωσης έχουν αποβληθεί με ειδήσεις και εικασίες σχετικά με μια νέα παραλλαγή του SARS-COV-2, του ιού που είναι υπεύθυνος για το Covid-19.

Η παραλλαγή, την οποία οι ερευνητές που εντοπίστηκαν για πρώτη φορά στο Ηνωμένο Βασίλειο, ονομάζεται b.1.1.7, αν και καθώς οι επιστήμονες άρχισαν να εκφράζουν την ανησυχία τους, τα αρχικά κυβερνητικά έγγραφα του Ηνωμένου Βασιλείου το ονομάζονταν vui – 202012/01, στέκονται για “Η πρώτη παραλλαγή υπό έρευνα τον Δεκέμβριο του 2020.”

Αργότερα κυβερνητικά έγγραφα από τον Δεκέμβριο το χαρακτήρισαν ως “παραλλαγή ανησυχίας” και αναφέρθηκαν σε αυτό ως VOC 202012/01.

B.1.1.7 εντοπίστηκε για πρώτη φορά στο Ηνωμένο Βασίλειο το Σεπτέμβριο του 2020. Άρχισε να εφιστά την προσοχή από την επιστημονική κοινότητα και τις κυβερνητικές αρχές στις αρχές Δεκεμβρίου, όταν ο υπουργός Υγείας του Ηνωμένου Βασιλείου, Matt Hancock, πρότεινε ότι αυτό εξαπλώθηκε γρήγορα και πιθανώς συμβάλλει στον αυξανόμενο αριθμό λοιμώξεων SARS-COV-2 στη νότια Αγγλία.

Τώρα, κατά τη στιγμή της δημοσίευσης αυτού του άρθρου, η νέα παραλλαγή έχει εντοπιστεί σε τουλάχιστον 60 χώρες.

Αλλά γιατί αυτή η παραλλαγή τόσο μεγάλου ενδιαφέροντος για τους επιστήμονες, τους οργανισμούς δημόσιας υγείας και το ευρύ κοινό γενικότερα; Σε αυτό το ειδικό χαρακτηριστικό, εξετάζουμε αυτό που γνωρίζουμε μέχρι στιγμής για το b.1.1.7 και εξετάζουμε τις ερωτήσεις που οι επιστήμονες εξακολουθούν να προσπαθούν να απαντήσουν.

Παρακάτω, διερευνούμε ποιες μεταλλάξεις είναι, πώς σχετίζονται με την ανάπτυξη νέων ιογενών στελεχών και αν η νέα παραλλαγή SARS-COV-2 που προσδιορίζεται στο Ηνωμένο Βασίλειο αποτελεί αιτία ανησυχίας.

Επίσης, η MNT έχει έρθει σε επαφή με την Pfizer και το Εθνικό Ινστιτούτο Αλλεργίας και Μολυσματικών Ασθενειών (NIAID) για να διαπιστωθεί εάν τα εμβόλια Covid-19 που είναι διαθέσιμα σήμερα στις Ηνωμένες Πολιτείες και την Ευρώπη θα είναι αποτελεσματικά έναντι του Β ένα .1.1.7. Μάθετε τι έπρεπε να μας πουν.

Περίληψη άρθρου:

Γιατί μεταλλάσσονται οι ιοί;

Οι ιοί είναι επιρρεπείς σε μεταλλάξεις. Πράγματι, όλο το γενετικό υλικό, συμπεριλαμβανομένου του ανθρώπινου, μπορεί να μεταλλαχθεί όταν τα λάθη συμβαίνουν κατά τη διάρκεια της αναπαραγωγής.

Μια μετάλλαξη ενός ιού συμβαίνει όταν υπάρχει αλλαγή στη γενετική του αλληλουχία. Αυτό δημιουργεί παραλλαγές και οδηγεί την εξέλιξη του ιού.

Οι μεταλλάξεις οδηγούν σε αλλαγές στις πρωτεΐνες που κωδικοποιούνται στον ιικό γενετικό κώδικα. Αυτές οι αλλαγές μπορούν είτε να είναι επωφελείς, επιβλαβείς είτε ουδέτερες.

Πόσες μεταλλάξεις χρειάζονται για να παράγουν ένα νέο στέλεχος του ιού; Αυτό δεν είναι εύκολο να απαντηθεί, εν μέρει επειδή οι επιστήμονες διαφωνούν για τον ορισμό της λέξης “στέλεχος”.

Γενικά, εάν ένας ιός έχει αρκετές μεταλλάξεις για να κάνει τη βιολογία του σημαντικά διαφορετική, μπορεί να είναι ένα νέο στέλεχος. Αυτό σημαίνει ότι μπορεί να ανταποκριθεί διαφορετικά σε εμβόλια ή θεραπείες ή μπορεί να μολύνει ένα διαφορετικό είδος ή να μεταδίδει με διαφορετικό τρόπο.

Αν όμως η βιολογία του ιού παραμένει ευρέως η ίδια, παρά τις μεταλλάξεις, ο όρος “παραλλαγή” μπορεί να είναι πιο επιστημονικά ακριβής.

Από την έναρξη της πανδημίας, υπήρξε μεγάλη συζήτηση για τις μεταλλάξεις SARS-COV-2 και ποιες συνέπειες μπορεί να έχουν.

Το SARS-COV-2, όπως και πολλοί άλλοι κοροναϊοί, έχει ένα ένζυμο που διορθώνει τον γενετικό του κώδικα κατά τη διάρκεια της αναπαραγωγής, μειώνοντας τον ρυθμό μεταλλάξεων.

Ενώ ο μυθιστόρημα του κοροναϊού έχει ένα σχετικά σταθερό γονιδίωμα, σε σύγκριση με άλλους τύπους ιού, μερικές φορές μεταλλάσσεται και οι επιστήμονες έχουν παρακολουθήσει στενά αυτές τις αλλαγές.

Μια από τις πιο ευρέως μιλήσει για μεταλλάξεις έχει οδηγήσει στην παραλλαγή D614G. Αυτό προκαλεί μια αλλαγή στην πρωτεΐνη ακίδων, η οποία αλληλεπιδρά με τον υποδοχέα ACE2 σε ανθρώπινα κύτταρα για να διευκολύνει την είσοδο του ιού.

Συγκεκριμένα, ένα αμινοξύ στην πρωτεΐνη ακίδων στη θέση 614 αλλάζει από ασπαρτικό οξύ σε γλυκίνη.

Έρευνα από τον Dr. Bette Korber, από το Εθνικό Εργαστήριο Los Alamos, στο Νέο Μεξικό, και οι συνάδελφοί τους υποδηλώνουν ότι αυτή η αλλαγή επιτρέπει την παραλλαγή να μολύνει τους ανθρώπους πιο εύκολα.

Η παραλλαγή D614G έχει γίνει η κυρίαρχη παραλλαγή του SARS-COV-2 παγκοσμίως, δείχνει η έρευνα.

Τα δεδομένα της ομάδας δείχνουν ότι τα άτομα με την παραλλαγή D614G του ιού μπορεί να έχουν υψηλότερα επίπεδα ιικού RNA από ό, τι τα άτομα με την αρχική παραλλαγή. Αλλά κανένα στοιχείο δεν δείχνει ότι αυτό προκαλεί πιο σοβαρή COVID-19.

Ακόμα, δεν συμφωνούν όλοι οι επιστήμονες με την ερμηνεία αυτής της ομάδας. Αναφερόμενος στο έγγραφο, ο Δρ. Nathan Grubaugh, από τη Σχολή Δημόσιας Υγείας του Yale, στο New Haven, CT, και οι συνεργάτες του, σχολίασαν ότι απαιτούνται περισσότερες έρευνες για να υποστηριχθεί η ιδέα ότι αυτή η παραλλαγή είναι πράγματι πιο μεταδοτική.

Ενώ οι ερευνητές συνεχίζουν να μελετούν τις διαφορές μεταξύ των παραλλαγών D και G, ο κόσμος έχει επικεντρωθεί στο B.1.1.7 και πώς μπορεί να διαμορφώσει την πορεία της πανδημίας.

b.1.1.7 και το φαινόμενο του ιδρυτή

Η παραλλαγή B.1.1.7 έχει 23 μεταλλάξεις. Έξι δεν προκαλούν αλλαγή στην αλληλουχία αμινοξέων του ιού. Από τις υπόλοιπες 17 μεταλλάξεις, οκτώ επηρεάζουν την πρωτεΐνη ακίδων.

Η αλλαγή N501Y, η οποία περιλαμβάνει μια μετάβαση από ασπαραγίνη σε τυροσίνη στη θέση 501, βρίσκεται στην περιοχή δέσμευσης υποδοχέα της πρωτεΐνης Spike. Αυτό είναι ένα κρίσιμο τμήμα, καθώς αλληλεπιδρά άμεσα με τον υποδοχέα ACE2.

Μια άλλη μετάλλαξη στο RNA που κωδικοποιεί την πρωτεΐνη Spike επιτρέπει στους ερευνητές να ανιχνεύσουν αυτή την παραλλαγή σε δείγματα δοκιμής αλυσιδωτής αντίδρασης πολυμεράσης (PCR). Αυτό οφείλεται στο γεγονός ότι η μετάλλαξη βρίσκεται σε μία από τις στοχευμένες περιοχές που χρησιμοποιούν πολλές διαγνωστικές δοκιμές PCR.

Αυτές οι δοκιμές χρησιμοποιούν επίσης άλλους στόχους, συνήθως ένα συνδυασμό τουλάχιστον δύο. Οι επιστήμονες μπορούν να αναζητήσουν δοκιμές PCR που είναι αρνητικές για την ακολουθία ακίδων αλλά θετικές για τους άλλους στόχους. Αυτό θα έδειχνε ότι το άτομο έχει την παραλλαγή b.1.1.7 του ιού SARS-COV-2.

Οι ερευνητές από τη δημόσια υγεία της Αγγλίας χρησιμοποίησαν αυτή τη μέθοδο για να παρακολουθήσουν την εξάπλωση της παραλλαγής στον βρετανικό πληθυσμό και να εκτιμήσουν τον τρόπο με τον οποίο η μεταδόση του σε σύγκριση με τις προηγούμενες παραλλαγές.

Αλλά μελετώντας πόσο εύκολα μεταδίδεται ένας ιός από το ένα άτομο στο άλλο είναι τεχνικά προκλητική. Τα επιδημιολογικά δεδομένα μπορούν να παρέχουν μοντέλα και οι εργαστηριακές έρευνες για τη δυναμική της λοίμωξης μπορούν να αποκαλύψουν περισσότερες λεπτομέρειες. Τέτοιες μελέτες βρίσκονται σε εξέλιξη.

Ορισμένοι επιστήμονες έχουν θέσει υπό αμφισβήτηση εάν η παραλλαγή b.1.1.7 έχει υψηλότερο ποσοστό μεταδόσεως, υποδηλώνοντας ότι ο μεγάλος αριθμός αυτών των περιπτώσεων μόλυνσης μπορεί να προκύψει από το φαινόμενο του ιδρυτή.

Το φαινόμενο του ιδρυτή είναι ένας όρος που χρησιμοποιούνται από επιστήμονες που μελετούν την εξέλιξη. Ορίζει ότι μια μικρή ομάδα ατόμων μπορεί να προκαλέσει νέο πληθυσμό.

Στο πλαίσιο των ιών, το φαινόμενο του ιδρυτή θα μπορούσε να εξηγήσει πώς έχει εξαπλωθεί τόσο γρήγορα το B.1.1.7. Οι ερευνητές πρότειναν ότι τα επιθετικά γεγονότα και η αύξηση των ποσοστών μόλυνσης σε όλη την Αγγλία μπορεί να είναι ο λόγος για τόσο μεγάλο αριθμό λοιμώξεων με την παραλλαγή B.1.1.7.

Μιλήσαμε σε δύο ειδικούς για αυτό.

“Ενώ αυτό αρχικά θεωρήθηκε δυνατή όταν η παραλλαγή εντοπίστηκε για πρώτη φορά τον Σεπτέμβριο, τα αποδεικτικά στοιχεία έχουν δείξει όλο και περισσότερο ότι αυτό είναι απίθανο και έχει πλέον αποκλειστεί σε μεγάλο βαθμό”, ο καθηγητής Martin Hibberd, καθηγητής αναδυόμενης Η μολυσματική ασθένεια στη Σχολή Υγιεινής και Τροπικής Ιατρικής του Λονδίνου (LSHTM), στο Ηνωμένο Βασίλειο, μας είπε.

Καθηγητής Jonathan Stoye, ηγέτης ομάδας στο Ινστιτούτο Francis Crick, στο Λονδίνο, του οποίου οι αλληλεπιδράσεις του ιού του εργαστηρίου, επανέλαβαν αυτό το συναίσθημα. “Αρχικά σκέφτηκα ότι αυτό θα μπορούσε να συμβεί”, σημείωσε, προσθέτοντας:

“Αν και θα μπορούσε να συμβάλει στην αρχική εξάπλωση της νέας παραλλαγής, φαίνεται απίθανο να εξηγηθεί η πολύ αυξημένη επίπτωση των περιπτώσεων, Δεδομένης της ταυτόχρονης αύξησης του ποσοστού της παραλλαγής σε πολλαπλές ρυθμίσεις. Αντίθετα, φαίνεται πιθανό ότι τα υψηλότερα επίπεδα απελευθέρωσης του ιού, ίσως από τη μόλυνση περισσότερων κυττάρων, οδηγούν σε υψηλότερα ποσοστά μετάδοσης του ιού. ”

– Καθηγητής Jonathan Stoye

ακριβώς πώς είναι b.1.1.7 διαφορετικό;

Πολλές ερωτήσεις σχετικά με το b.1.1.7. παραμένει. Πώς συγκρίνεται με τα προϋπάρχοντα στελέχη, από την άποψη της μεταδόσεως; Είναι πιθανό να προκαλέσει πιο σοβαρή COVID-19; Είναι τα παιδιά πιο ευάλωτα σε αυτήν την παραλλαγή;

Η διαθέσιμη έρευνα φαίνεται να δείχνει ότι η νέα παραλλαγή έχει υψηλότερο βαθμό μεταδόσεως.

Μια μελέτη, η οποία δεν έχει ακόμη αξιολογηθεί, αλλά η οποία έγινε διαθέσιμη στον διακομιστή Preprint στις 26 Δεκεμβρίου 2020, χρησιμοποίησε μαθηματική μοντελοποίηση για να εκτιμήσει το μεταδιδακτορικό της νέας παραλλαγής, σε σύγκριση με εκείνη των “προϋπάρχουσων παραλλαγών του SARS-CoV-2.”

Η ομάδα των ερευνητών, από το LSHTM, καταλήγει στο συμπέρασμα ότι η παραλλαγή B.1.1.7 είναι 56% πιο μεταδιδόμενη “από άλλες παραλλαγές SARS-COV-2.

Εν τω μεταξύ, μια αναφορά, επίσης σε μορφή preprint, από το Imperial College London, εξετάζει σήμερα τα διαθέσιμα επιδημιολογικά και γενετικά δεδομένα και επίσης καταλήγει στο συμπέρασμα ότι το b.1.1.7 φαίνεται να έχει υψηλότερη μεταδοτική από τις άλλες παραλλαγές του SARS- COV-2.

Οι ερευνητές εκτιμούν ότι το b.1.1.7 είναι 50-75% πιο μεταδοτικό και θεωρούν το αποτέλεσμα του ιδρυτή στην ανάλυσή τους. Ωστόσο, τα δεδομένα τους μιλάνε υπέρ ενός ανταγωνιστικού πλεονεκτήματος αυτής της παραλλαγής σε σχέση με τις προηγούμενες παραλλαγές που βασίζονται σε αυξημένο μεταδιδακτορικό. Ωστόσο, ο Δρ Julian W. Tang, κλινικός ιολόγος στο Πανεπιστήμιο του Leicester, στο Ηνωμένο Βασίλειο, έχει προειδοποιήσει ότι «είναι ακόμα δύσκολο να διαχωριστούν οι ανθρώπινες συμπεριφορικές και οι ιογενείς γενετικές συνεισφορές ως αιτίες για ενισχυμένη μεταδόσεις σε όλους τους πληθυσμούς, “προσθέτοντας ότι” στην πράξη, πρέπει απλώς να αντιμετωπίσουμε αυτό “.

Πληροφορίες από τη δημόσια υγεία Η Αγγλία που ενημερώθηκε τελευταία στις 29 Δεκεμβρίου 2020, σημειώνει ότι υπάρχει “επί του παρόντος […] καμία απόδειξη ότι η παραλλαγή είναι πιο πιθανό να προκαλέσει σοβαρή ασθένεια ή θνησιμότητα”, αν και σε εξέλιξη περαιτέρω έρευνες βρίσκονται σε εξέλιξη .

Ο καθηγητής Hibberd δήλωσε στο MNT ότι με βάση τα υπάρχοντα δεδομένα από το Ηνωμένο Βασίλειο, η νέα παραλλαγή δεν φαίνεται να οδηγεί σε πιο σοβαρές περιπτώσεις Covid-19, σε σύγκριση με άλλες παραλλαγές ή στελέχη του SARS-COV-2 .

“Το ποσοστό θνησιμότητας της περίπτωσης μόλυνσης, που βασίζεται σε κοινοτικές πληθυσμιακές εκτιμήσεις για τον αριθμό των ατόμων [με λοίμωξη] και τον αριθμό των θανάτων που παρατηρήθηκαν-που εκτιμήθηκαν από τα δεδομένα στο Ηνωμένο Βασίλειο- δεν φαίνεται να έχει αλλάξει σημαντικά, υποδηλώνοντας ότι η νέα παραλλαγή δεν προκαλεί πιο σοβαρή ασθένεια », είπε.

συγκρίνοντας άμεσα τις νέες και παλιές παραλλαγές. Όμως, καθώς η παλιά παραλλαγή γίνεται σπάνια στο Ηνωμένο Βασίλειο, αυτό θα γίνει όλο και πιο δύσκολο. Καθώς η παραλλαγή φτάνει σε άλλες χώρες, όπως οι Η.Π.Α., θα είναι διαθέσιμα περαιτέρω δεδομένα. ”

Αντίκτυπος στα μέτρα δημόσιας υγείας

Η ταχεία εξάπλωση των λοιμώξεων στο Ηνωμένο Βασίλειο – κατηγορήθηκε σε μεγάλο βαθμό στην παραλλαγή B.1.1.7 – καθ ‘όλη τη διάρκεια του Δεκεμβρίου του 2020 οδήγησε πρώτα σε τοπικούς περιορισμούς , στη συνέχεια στην επιβολή αυστηρών κλειδώματος στην Αγγλία και τη Σκωτία. Η Ιρλανδία έχει παρατείνει το σε εθνικό επίπεδο κλείδωμα, με αυστηρότερους κανόνες.

Στην έκδοση Preprint της μελέτης LSHTM, οι ερευνητές προειδοποιούν ότι δεδομένης της φαινομενικά υψηλότερης μεταδόσεως της νέας παραλλαγής, “τα υπάρχοντα μέτρα ελέγχου [για τη συγκράτηση της εξάπλωσης του ιού] είναι πιθανό να είναι λιγότερο αποτελεσματικά και οι χώρες μπορεί να απαιτεί ισχυρότερες προληπτικές παρεμβάσεις για την επίτευξη του ίδιου επιπέδου ελέγχου. ”

Σε δήλωση που δημοσιεύθηκε στις 31 Δεκεμβρίου 2020, ο Παγκόσμιος Οργανισμός Υγείας (ΠΟΥ) σημείωσε ότι αρκετές χώρες παίρνουν ήδη τα μέτρα που μπορούν για να παραμείνουν μπροστά από το παιχνίδι.

Οι χώρες που έχουν παρατηρήσει την εξάπλωση των νέων παραλλαγών ιών έχουν “εντατικοποιήσει τη δειγματοληψία για να κατανοήσουν πόσο ευρέως κυκλοφορούν αυτές οι νέες παραλλαγές” και οι επιστήμονες έχουν επιταχύνει τις προσπάθειες για να κατανοήσουν εάν ή πώς οι νέες παραλλαγές SARS-COV-2-2 μπορεί να επηρεάσει τη μετάδοση, τη σοβαρότητα της νόσου και την αποτελεσματικότητα του εμβολίου, σύμφωνα με τη δήλωση.

Οι που έχουν επίσης συστήσει ότι «οι δραστηριότητες επικοινωνίας και της κοινότητας κινδύνου είναι κλιμακωμένοι για να εξηγήσουν τις συνέπειες της δημόσιας υγείας των παραλλαγών SARS-COV-2 στο κοινό και να τονίσουν τη σημασία της διατήρησης των συνεχιζόμενων προληπτικών μέτρων Για να μειώσετε τη μετάδοση. ”

Μια αναπάντητη ερώτηση σχετικά με το b.1.1.7 αφορά την ευαισθησία των παιδιών στη νέα παραλλαγή.

Στο Ηνωμένο Βασίλειο, τα σχολεία ήταν σε μεγάλο βαθμό ανοιχτά κατά τη διάρκεια της πτώσης, αλλά πρόσφατα έκλεισαν για τα περισσότερα παιδιά. Μερικοί επιστήμονες πρότειναν ότι τα παιδιά είναι πιο πιθανό να αναπτύξουν μια λοίμωξη με B.1.1.7 από ό, τι με τις προηγούμενες παραλλαγές του SARS-COV-2.

Ωστόσο, δεν υπάρχει συναίνεση μεταξύ της επιστημονικής κοινότητας.

“Καθώς τα παιδιά είναι συχνά ασυμπτωματικά, ήταν δύσκολο να εκτιμηθούν τα αληθινά ποσοστά μόλυνσης που βασίζονται στον πληθυσμό. Τα αρχικά δεδομένα φαίνεται να υποδηλώνουν ότι περισσότεροι έφηβοι γίνονται θετικοί, αλλά τα δεδομένα είναι επί του παρόντος ασαφή “, εξήγησε ο καθηγητής Hibberd.

Ο καθηγητής Stoye μοιράστηκε αυτή την άποψη: “Δεδομένου ότι ένας πιο μεταδοτικός ιός, φαίνεται αναπόφευκτο ότι περισσότερα παιδιά θα έχουν μια μόλυνση με τη νέα παραλλαγή και στη συνέχεια θα [μεταβιβάσουν αυτό] στις οικογένειές τους. Δεν μπορώ να σχολιάσω τον αντίκτυπο της λοίμωξης στην υγεία των μεμονωμένων παιδιών. Περισσότερες μελέτες […] θα απαιτηθούν για την επίλυση αυτής της ερώτησης. ”

εμβόλια covid-19 και η νέα παραλλαγή

Σύμφωνα με τον καθηγητή Stoye, υπάρχουν ανησυχίες ότι σήμερα εξουσιοδοτημένα εμβόλια ενδέχεται να μην είναι εξίσου αποτελεσματικά έναντι νέων παραλλαγών του SARS-COV-2 ως Είναι ενάντια στις προϋπάρχουσες παραλλαγές που συμμετείχαν στη δοκιμή κατά τη διάρκεια κλινικών δοκιμών.

“Ένας τομέας ανησυχίας αφορά την πιθανότητα ότι οι νέες παραλλαγές θα παρουσιάσουν μειωμένη ευαισθησία στις ανοσοαποκρίσεις στα πρόσφατα εισαγόμενα εμβόλια”, δήλωσε ο καθηγητής Stoye στο MNT. “Ενώ φαίνεται απίθανο οι τρέχουσες παραλλαγές να ξεφύγουν, οι μελλοντικές παραλλαγές θα μπορούσαν να το κάνουν”.

“Θα είναι σημαντικό να παρακολουθείτε νέους ιούς για εξουδετέρωση από ορούς [ένα συστατικό αίματος] από εμβολιασμένα άτομα. Στο μέλλον, μπορεί να χρειαστεί να αλλάξετε τη σύνθεση του εμβολίου με τον τρόπο που κάνουμε με τη γρίπη, αλλά ελπίζουμε όχι τόσο συχνά “, πρόσθεσε.

Η MNT ήρθε σε επαφή με την NIAID, έναν οργανισμό στο πλαίσιο των Εθνικών Ινστιτούτων Υγείας (NIH) που είχε συνεργαστεί με την εταιρεία Biotechnology Moderna για να δημιουργήσει ένα εμβόλιο Covid-19 που είναι εξουσιοδοτημένο για χρήση στις ΗΠΑ και το Ηνωμένο Βασίλειο που εξήγησαν:

“Οι επιστήμονες της NIAID έχουν επικοινωνήσει με τους ομολόγους της στη Δημόσια Υγεία Αγγλία, μέρος της κυβέρνησης του Ηνωμένου Βασιλείου, για να παρακολουθήσουν στενά την κατανόησή τους για το SARS-COV-2 VOC 202012/01, επίσης γνωστή ως παραλλαγή του Ηνωμένου Βασιλείου.

Επί του παρόντος, οι επιστήμονες NIAID πιστεύουν ότι τα εμβόλια SARS-COV-2 που υποστηρίζονται από την ταχύτητα λειτουργίας Warp [OWS] θα παρέχουν προστασία έναντι SARS-COV-2 VOC 202012/01, συμπεριλαμβανομένης της Moderna και της Moderna και της Moderna και Τα εμβόλια Pfizer-BionTech Covid-19 εξουσιοδοτημένα για χρήση έκτακτης ανάγκης από την Υπηρεσία Τροφίμων και Φαρμάκων των Η.Π.Α. [FDA]. ”

“Ως μέρος της ανοσοαπόκρισης ενός ατόμου στο εμβόλιο, παράγουν πολλά αντισώματα που δεσμεύονται σε διαφορετικές θέσεις στην πρωτεΐνη ακίδων στην επιφάνεια του ιού SARS-CoV-2. Ακόμη και αν μια παραλλαγή SARS-COV-2 έχει μερικές μεταλλάξεις που εμποδίζουν τη δέσμευση ορισμένων αντισωμάτων, οι επιστήμονες αναμένουν ότι άλλα αντισώματα με διαφορετικές ιδιότητες δέσμευσης θα εξουδετερώσουν τον ιό “, δήλωσε επίσης ο Niaid στο MNT.

Η φαρμακευτική εταιρεία Pfizer, της οποίας το εμβόλιο Covid-19-που δημιουργήθηκε σε συνεργασία με την εταιρεία βιοτεχνολογίας Biontech-έχει αποκτήσει εξουσιοδότηση στις ΗΠΑ, το Ηνωμένο Βασίλειο και την Ευρωπαϊκή Ένωση, έκανε παρόμοια δήλωση:

“Η ταυτοποίηση μιας νέας παραλλαγής του ιού SARS-COV-2 δεν επηρεάζει την ανάπτυξη του εμβολίου Pfizer και Biontech Covid-19 mRNA BNT162B2. Οι επαγγελματίες υγείας συνιστώνται να συνεχίσουν να ακολουθούν την επίσημη καθοδήγηση σχετικά με τη διαχείριση του εμβολίου. ”

πρόσθεσαν ότι “οι εταιρείες [Pfizer και BionTech] παρακολουθούν τις αλλαγές αλληλουχίας SARS-COV-2 και εργάζονται για τη δημιουργία δεδομένων για να αξιολογήσουν τον τρόπο με τον οποίο εμείςl Ο ορός από άτομα που ανοσοποιήθηκαν με BNT162B2 μπορεί να είναι σε θέση να εξουδετερώσει το νέο στέλεχος. ”

ελπιδοφόρα ευρήματα και προσαρμόσιμη τεχνολογία

Σε συνεργασία με επιστήμονες στο Ιατρικό Υποκατάστημα του Πανεπιστημίου του Τέξας στο Galveston, η Pfizer δημοσίευσε πρόσφατα μια μελέτη, σήμερα σε μορφή προτύπου, στην οποία εξέτασαν το N501Y μετάλλαξη.

Χρησιμοποιώντας δείγματα ορού από εθελοντές που είχαν λάβει το εμβόλιο Pfizer-BionTech Covid-19 σε κλινική δοκιμή, οι ερευνητές ανέλυσαν πόσο καλά τα αντισώματα στα δείγματα θα μπορούσαν να εξουδετερώσουν τον ιό SARS-COV-2.

Διαπίστωσαν ότι οι οροί είχαν “ισοδύναμες εξουδετερωτικούς τίτλους”, πράγμα που σημαίνει ότι η ίδια ποσότητα ορού ήταν σε θέση να εξουδετερώσει τόσο τον αρχικό ιό όσο και την μεταλλαγμένη παραλλαγή. Αυτό δείχνει ότι το εμβόλιο θα λειτουργήσει εξίσου καλά κατά της παραλλαγής.

Ωστόσο, η ομάδα μελέτησε μόνο τη μετάλλαξη N501Y σε απομόνωση και το B.1.1.7 έχει μια σειρά μεταλλάξεων στην πρωτεΐνη ακίδων της.

Σε συνέντευξη Τύπου στις 22 Δεκεμβρίου 2020, ο Δρ Uğur şahin, Διευθύνων Σύμβουλος της Biontech, εξήγησε ότι η εταιρεία είχε δοκιμάσει προηγουμένως το εμβόλιο τους σε συνδυασμό με αρκετές παραλλαγές SARS-COV-2 και βρέθηκε ότι λειτούργησε καλά εναντίον αυτών. Αυτά τα ευρήματα είναι διαθέσιμα σε μορφή preprint.

Ο Δρ. şahin πρόσθεσε ότι η εταιρεία θα μπορούσε εύκολα να προσαρμόσει την πλατφόρμα εμβολίων για την καταπολέμηση νέων παραλλαγών.

Το εμβόλιο Pfizer-BionTech Covid-19 βασίζεται στην τεχνολογία mRNA. Αυτό σημαίνει ότι το εμβόλιο περιέχει μια μικρή ποσότητα του γενετικού κώδικα του SARS-COV-2 που παράγεται σε ένα εργαστήριο. Μόλις εγχυθεί ως εμβόλιο, αυτός ο κώδικας καθοδηγεί τα δικά μας κύτταρα να φτιάξουν την ιογενή πρωτεΐνη ακίδων.

Το ανοσοποιητικό μας σύστημα αντιδρά σε αυτήν την κατασκευασμένη πρωτεΐνη ακίδων και δημιουργεί ανοσία στον ιό SARS-COV-2. Σε καμία περίπτωση δεν θα μπορούσε το εμβόλιο να προκαλέσει COVID-19 επειδή δεν περιέχει ζωντανά παθογόνα.

Τεχνικά, δεν θα ήταν δύσκολο να αλλάξει η ακολουθία του γενετικού κώδικα στο εμβόλιο έτσι ώστε να ταιριάζει με αυτή της νέας παραλλαγής. Ο Δρ. Şahin εκτιμά ότι αυτό θα διαρκέσει περίπου 6 εβδομάδες. Σημείωσε, ωστόσο, ότι οι υγειονομικές αρχές όπως ο FDA θα πρέπει να εγκρίνουν οποιαδήποτε αλλαγή στο εμβόλιο προτού να μπορέσει να χορηγηθεί.

Στις 25 Ιανουαρίου 2021, η Moderna δημοσίευσε επίσης ένα δελτίο τύπου που ανακοινώνει ότι το εμβόλιο τους είναι αποτελεσματικό έναντι της παραλλαγής B.1.1.7. “Το σχήμα δύο δόσεων του εμβολίου Moderna Covid-19 στη δόση 100 [μικρογραμμάρια] αναμένεται να προστατεύεται από αναδυόμενα στελέχη που ανιχνεύονται μέχρι σήμερα”, δηλώνουν.

Η εταιρεία δεν έχει ακόμη δημοσιεύσει δεδομένα που υποστηρίζουν αυτούς τους ισχυρισμούς. Παρ ‘όλα αυτά, οι Moderna αξιωματούχοι δήλωσαν επίσης ότι “από την αφθονία της προσοχής”, ξεκινούν ένα κλινικό πρόγραμμα στο οποίο θα συνεχίσουν να δοκιμάζουν την αποτελεσματικότητα του εμβολίου έναντι των νέων παραλλαγών SARS-COV-2 και ότι η εταιρεία στοχεύει στην αύξηση της παραγωγής του εμβολίου των τίτλων εξουδετέρωσης σε τέτοιες παραλλαγές.

Σε μια κλινική δοκιμή φάσης 1, η Moderna θα ελέγξει έτσι εάν η λογιστική των ειδικών για το στέλεχος πρωτεΐνες ακίδων θα βελτίωνε την αποτελεσματικότητα του εμβολίου.

Η φαρμακευτική εταιρεία AstraZeneca και η ομάδα εμβολίων της Οξφόρδης δεν απάντησαν στο αίτημα του MNT για σχόλια σχετικά με την αποτελεσματικότητα του εμβολίου κατά της παραλλαγής B.1.1.7.

Μια άλλη νέα παραλλαγή

Ενώ ένα μεγάλο μέρος των ειδήσεων έχει επικεντρωθεί στο b.1.1.7, έχει προκύψει μια άλλη νέα παραλλαγή. Πρώτα προσδιορίστηκε στη Νότιο Αφρική, η παραλλαγή B.1.351 έχει επίσης την αλλαγή αμινοξέων N501Y στην πρωτεΐνη ακίδων της.

Έχει επίσης δύο πρόσθετες μεταλλάξεις στην περιοχή αυτή, προκαλώντας περαιτέρω ανησυχίες σχετικά με το πόσο αποτελεσματικός θα είναι ο εμβολιασμός. Ορισμένοι ακαδημαϊκοί εμπειρογνώμονες έχουν πει στο Science Media Center, στο Ηνωμένο Βασίλειο, ότι πιστεύουν ότι τα υπάρχοντα εμβόλια Covid-19 μπορούν να καταπολεμήσουν αυτή την παραλλαγή.

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